Species Human Entrez 8664 | Human Mouse Ensembl ENSG00000100353 | |
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Aliases EIF3D, EIF3S7, eIF3-p66, eIF3-zeta, eukaryotic translation initiation factor 3 subunit D External IDs MGI: 1933181 HomoloGene: 2782 GeneCards: EIF3D | ||
Eukaryotic translation initiation factor 3 subunit D is a protein that in humans is encoded by the EIF3D gene.
Contents
Function
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.
Interactions
EIF3D has been shown to interact with PHLDA1 and EIF3A.
References
EIF3D Wikipedia(Text) CC BY-SA