Species Human Entrez 9451 | Human Mouse Ensembl ENSG00000172071 | |
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Aliases EIF2AK3, PEK, PERK, WRS, eukaryotic translation initiation factor 2 alpha kinase 3 External IDs MGI: 1341830 HomoloGene: 3557 GeneCards: EIF2AK3 | ||
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.
Contents
Function
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.
Clinical significance
Patients with mutations in this gene develop Wolcott-Rallison syndrome.
Interactions
EIF2AK3 has been shown to interact with DNAJC3 and NFE2L2.
Inhibitors
References
EIF2AK3 Wikipedia(Text) CC BY-SA