Samiksha Jaiswal (Editor)

EIF1AX

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Species
  
Entrez
  
1964

Human
  
Ensembl
  
ENSG00000173674

EIF1AX

Aliases
  
EIF1AX, EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C, eukaryotic translation initiation factor 1A, X-linked

External IDs
  
MGI: 95298 HomoloGene: 20364 GeneCards: EIF1AX

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene. This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.

Contents

Function

eIF1A is a small proteins (17 kDa in budding yeast) and a component of the 43S preinitiation complexes (PIC). eIF1A binds near the ribosomal A-site, in a manner similar to the functionally related bacterial counterpart IF1.

Clinical significance

Mutations in this gene have been recurrently seen associated to cases of uveal melanoma with disomy 3.

Interactions

EIF1AX has been shown to interact with IPO13.

References

EIF1AX Wikipedia


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