Species Human Entrez 10209 | Human Mouse Ensembl ENSG00000173812 | |
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Aliases EIF1, A121, EIF-1, EIF1A, ISO1, SUI1, eukaryotic translation initiation factor 1, Eukaryotic initiation factor 1 External IDs HomoloGene: 130538 GeneCards: EIF1 | ||
Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene.
eIF1 interacts with the eukaryotic small (40S) ribosomal subunit and eIF3, and is a component of the 43S preinitiation complex (PIC). eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC) during eukaryotic translation initiation. eIF1 binds to a region near the ribosomal A-site in the 40S subunit and functions in a manner similar to the structurally related bacterial counterpart IF1.
References
EIF1 Wikipedia(Text) CC BY-SA