Entrez 1938 | Ensembl ENSG00000167658 | |
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Aliases EEF2, EEF-2, EF-2, EF2, SCA26, eukaryotic translation elongation factor 2, Eukaryotic elongation factor 2 External IDs MGI: 95288 HomoloGene: 134867 GeneCards: EEF2 | ||
Gene music using protein sequence of eef2kmt eukaryotic elongation factor 2 lysine methyltransfera
Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene.
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.
It is the target of diphtheria toxin (from Corynebacterium diphtheriae), and exotoxin A (from Pseudomonas aeruginosa). The inactivation of EF-2 by toxins inhibits protein production in the host, causing symptoms due to loss function in affected cells.
References
EEF2 Wikipedia(Text) CC BY-SA