Puneet Varma


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Species  Human
Entrez  8721
Human  Mouse
Ensembl  ENSG00000107223
Aliases  EDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDs  MGI: 1891227 HomoloGene: 2809 GeneCards: EDF1

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.



This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.


EDF1 has been shown to interact with:

  • Liver X receptor alpha,
  • Peroxisome proliferator-activated receptor gamma, and
  • TATA binding protein.
  • References

    EDF1 Wikipedia

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