Entrez 1877 | Ensembl ENSG00000167967 | |
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Aliases E4F1, E4F, E4F transcription factor 1 External IDs MGI: 109530 HomoloGene: 3259 GeneCards: E4F1 | ||
Function
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.
Interactions
E4F1 has been shown to interact with:
References
E4F1 Wikipedia(Text) CC BY-SA