Supriya Ghosh (Editor)

E2F1

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Species
  
Entrez
  
1869

Human
  
Ensembl
  
ENSG00000101412

E2F1

Aliases
  
E2F1, E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1

External IDs
  
OMIM: 189971 MGI: 101941 HomoloGene: 3828 GeneCards: E2F1

Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.

Contents

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

Transcription

E2F1 promoter[PAX8] => E2F1 [PMID 21602887]

Interactions

E2F1 has been shown to interact with:

References

E2F1 Wikipedia


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