The Viscounty of Joyeuse was elevated to a Duchy in 1581 by King Henry III of France for his favourite Anne de Joyeuse.
1581-1587 : Anne de Joyeuse (1560 † 1587), son of Guillaume de Joyeuse and Marie de Batarnay.
1587-1592 : Antoine Scipion de Joyeuse (1565 † 1592), brother of the above.
1592-1608 : Henri de Joyeuse (1563 † 1608), brother of the above.
1608-1615 : cardinal François de Joyeuse (1562 † 1615), archbishop of Toulouse and Rouen, brother of the above.
1615-1647 : Henriette Catherine de Joyeuse (1585 † 1656), daughter of the above.
Henriette Catherine married twice: first to the vastly wealthy Henri de Bourbon, Duke of Montpensier; then to Charles de Lorraine, Duke of Guise. From her first marriage, she was the maternal grandmother of la Grande Mademoiselle. In 1647, Henriette Catherine gave the duchy to her son Louis de Lorraine.
1647-1654 : Louis de Lorraine (1622 † 1654), son of Henriette Catherine de Joyeuse.
1654-1671 : Louis Joseph de Lorraine (1650 † 1671), Duke of Guise and Joyeuse, son of the above.
1671-1675 : Francis Joseph de Lorraine, Duke of Guise and Joyesue, son of the above.
1675-1688 : Marie de Lorraine, Duchess of Guise, Princess of Joinville, daughter of Charles and Henriette Catherine of Joyeuse.
Without any heirs, Marie ceded the duchy of Joyeuse to her 3rd cousin once removed Charles François de Lorraine in 1688.
1688-1690 : Charles François de Lorraine (1661 † 1702), Prince of Commercy, grandson of Charles II, Duke of Elbeuf and nephiew of the previous.
1693-1693 : Jean Paul de Lorraine (1672 † 1693), Prince of Lillebonne, brother of the above, died without issue.
1693-1694 : François Marie de Lorraine (1624 † 1694), Prince of Lillebonne, Duke of Joyeuse, father of the above and youngest son of Charles II, Duke of Elbeuf.
1694-1714 : Anne de Lorraine (1639 † 1720), wife of the above, daughter of Charles IV, Duke of Lorraine. The duchy was transmitted to the grandson of François Marie and Anne, Louis de Melun, who was created Duke of Joyesue in 1714.
1714-1724 : Louis de Melun, Prince of Epinoy, Baron of Antoing then Duke of Joyeuse. Son of Louis de Melun and Élisabeth Thérèse de Lorraine. Élisabeth Thérèse, Princess of Epinoy, was the daughter of the previous duke and duchess of Joyeuse.
