Doxofylline

Medical uses

It has antitussive and bronchodilator effects, and acts as a phosphodiesterase inhibitor.

In animal and human studies, it has shown similar efficacy to theophylline but with significantly fewer side effects.

Chemistry

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase.

Names

It is marketed under many brand names worldwide, including: An Li Nuo Er, An Sai Ma, Ansimar, Asima, Bestofyline, Chuan Ning, D-Fyal, Dilatair, Doxiba, Doxobid, Doxobron, Doxofilina, Doxofillina, Doxofyllin, Doxofylline, Doxofylline, Doxofylline, Doxoll, Doxophylline , Doxovent, Doxyjohn, Fei Te Ai Si, Jian Fang Neng, Lang Ming, Lv Meng, Mai Ping Xi, Maxivent, Mucosma, Na De Lai, Phylex, Phyllin, Puroxan, Rexipin, Shu Zhi, Shuai An, Shuweixin, Suo Di, Suo Ji, Suo Li An, Xi Si Nuo, Xin Qian Ping, Xin Xi Ping, Yi Suo, and Yili.

It is also marketed as a combination drug with terbutaline as Doxoll-TL, Mucosma-T and Phylex-TR.

It is also marketed as a combination drug with montelukast as Doxoll-ML, Doxomont , Doxoril-M, Doxovent-M, Lunair-M, and Venidox-M.