Nationality United States Name Douglas Wallace | Fields Human genetics | |
Institutions Stanford University School of Medicine, Emory University, Human Genome Organisation, University of California, Irvine, Academia Sinica, University of Pennsylvania, Children's Hospital of Philadelphia Thesis Cytoplasmic genetics in mammalian tissue culture cells Notable awards Passano AwardGruber Prize in Genetics (2012) | ||
2015 usc school of medicine greenville luminaries of medicine lecture by dr douglas c wallace
Douglas Cecil Wallace (born November 6, 1946) is a geneticist and evolutionary biologist at the University of Pennsylvania and the Children's Hospital of Philadelphia in Pennsylvania. He pioneered the use of human mitochondrial DNA as a molecular marker.
Contents
- 2015 usc school of medicine greenville luminaries of medicine lecture by dr douglas c wallace
- Douglas c wallace 2017 laureate of the franklin institute in life science
- Career
- Work
- Honours and awards
- References
Douglas c wallace 2017 laureate of the franklin institute in life science
Career
Wallace earned a Bachelor of Science in Genetics and Developmental Biology at Cornell University in Ithaca, New York in 1968, a Master of Philosophy in Microbiology and Human Genetics at Yale University in New Haven, Connecticut in 1972 and a Ph.D. in Microbiology and Human Genetics at Yale University in 1975. His dissertation was titled Cytoplasmic genetics in mammalian tissue culture cells.
He remained at Yale University as a postdoctoral fellow until he was awarded a professorship (Assistant Professor) at the Stanford University School of Medicine in Stanford, California in 1976. In 1983 he became professor (Adjunct Professor) for Biochemistry, Anthropology and Pediatrics (Genetics) at the Emory University in Atlanta, Georgia. From 1996 to 2002, he was Chairperson and Senior Editor of the Mitochondrial DNA Locus-Specific Database for the Human Genome Organisation (HUGO). In 2002 he assumed a professorship of Molecular Genetics at the University of California, Irvine and founded the Center for Molecular and Mitochondrial Medicine and Genetics there. In 2006 he was awarded a visiting professorship at Academia Sinica in Taipei, Taiwan. In 2010 he became professor of Pathology and Laboratory Medicine at the University of Pennsylvania in Philadelphia and became the founding director of the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia.
Work
Wallace is a pioneer in the study of mitochondrial DNA. Wallace and his colleagues introduced human mitochondrial genetics into the field of molecular genetics. In 1975, for the first time ever, Wallace could associate a genetic disorder with the mitochondrial DNA region (resistance to chloramphenicol) and in 1990 he described a mitochondrial DNA mutation as the cause of a particular form of myoclonic epilepsy. He has been instrumental in the study of the mitochondrial genome and has developed new methods for the analysis of mitochondrial DNA.
Wallace and his colleagues demonstrated that human mitochondrial DNA is inherited exclusively from the mother and reconstructed the origin and ancient migration patterns of women using variations in mitochondrial DNA sequences.