Dolichylphosphate mannose phosphodiesterase

In enzymology, a dolichylphosphate-mannose phosphodiesterase (EC 3.1.4.49) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are dolichyl beta-D-mannosyl phosphate and H₂O, whereas its two products are dolichyl phosphate and D-mannose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is dolichyl-beta-D-mannosyl-phosphate dolichylphosphohydrolase. This enzyme is also called mannosylphosphodolichol phosphodiesterase.