Dolichylphosphate glucose phosphodiesterase

In enzymology, a dolichylphosphate-glucose phosphodiesterase (EC 3.1.4.48) is an enzyme that catalyzes the chemical reaction

dolichyl beta-D-glucosyl phosphate + H₂O ⇌ dolichyl phosphate + D-glucose

Thus, the two substrates of this enzyme are dolichyl beta-D-glucosyl phosphate and H₂O, whereas its two products are dolichyl phosphate and D-glucose.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase. Other names in common use include dolichol phosphoglucose phosphodiesterase, and Dol-P-Glc phosphodiesterase. This enzyme participates in n-glycan biosynthesis.