In enzymology, a dolichylphosphate-glucose phosphodiesterase (EC 18.104.22.168) is an enzyme that catalyzes the chemical reaction
dolichyl beta-D-glucosyl phosphate + H2
dolichyl phosphate + D-glucose
Thus, the two substrates of this enzyme are dolichyl beta-D-glucosyl phosphate and H2O, whereas its two products are dolichyl phosphate and D-glucose.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is dolichyl-beta-D-glucosyl-phosphate dolichylphosphohydrolase. Other names in common use include dolichol phosphoglucose phosphodiesterase, and Dol-P-Glc phosphodiesterase. This enzyme participates in n-glycan biosynthesis.