Group Group V ((-)ssRNA) Family Bunyaviridae Rank Species | Order Unassigned Genus Hantavirus | |
Similar Puumala virus, Seoul virus, Andes virus, Bunyaviridae, Striped field mouse | ||
Dobrava-Belgrade virus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Hantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated from yellow-necked mice (Apodemus flavicollis) found in Dobrava Village, Slovenia, Yugoslavia. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.
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Reservoir
Dobrava virus and the variants of Dobrava-Belgrade virus have been found in the Yellow-necked mouse [(Apodemus flavicollis) virus genotype Dobrava], the Striped field mouse [(Apodemus agrarius) virus genotype Kurkino] and Black Sea field mouse [(Apodemus ponticus) virus genotype Sochi].
Morbidity and mortality
The fatality rate is 12%, making Dobrava virus the most life-threatening hantavirus disease in Europe. Variant DOBV genotypes have different degrees of pathogenicity.