Routes of
administration Oral, Topical Biological half-life 24–40 hours CAS ID 147-20-6 | ATC code R06AA07 (WHO) Molar mass 281.392 g/mol | |
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AHFS/Drugs.com International Drug Names Legal status In general: ℞ (Prescription only) Synonyms 4-(diphenylmethoxy)-1-methyl-piperidine | ||
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.
Contents
Synthesis
Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine, is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.
Trade names
Arbid, Dafen, Dayfen, Histyn, Hispril, etc.
References
Diphenylpyraline Wikipedia(Text) CC BY-SA