Species Human Entrez 1800 | Human Mouse Ensembl ENSG00000015413 | |
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Aliases DPEP1, MBD1, MDP, RDP, dipeptidase 1 (renal) External IDs MGI: 94917 HomoloGene: 80192 GeneCards: DPEP1 | ||
Dipeptidase 1 is an enzyme that in humans is encoded by the DPEP1 gene.
Contents
Function
DPEP1 (EC 3.4.13.11) is a kidney membrane enzyme that hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates, e.g., leukotriene D4 (Kozak and Tate, 1982). DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics, such as penem and carbapenem (Campbell et al., 1984). Earlier, beta-lactamase enzymes were thought to occur only in bacteria, where their probable function was in protecting the organisms against the action of beta-lactam antibiotics. These antibiotics exhibit selective toxicity against bacteria but virtual inertness against many eukaryotic cells (Adachi et al., 1990).[supplied by OMIM]
Interactions
Dipeptidase 1 has been shown to interact with KIAA1279.