Dihydroxy acid dehydratase

Updated on Jan 12, 2024

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EC number 4.2.1.9 IntEnz IntEnz view ExPASy NiceZyme view		CAS number 9024-32-2 BRENDA BRENDA entry KEGG KEGG entry

In enzymology, a dihydroxy-acid dehydratase (EC 4.2.1.9) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxy-3-methylbutanoate ⇌ 3-methyl-2-oxobutanoate + H₂O

Hence, this enzyme has one substrate, 2,3-dihydroxy-3-methylbutanoate, and two products, 3-methyl-2-oxobutanoate (α-ketoisovaleric acid) and H₂O.

This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.

Nomenclature

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include

acetohydroxyacid dehydratase,

alpha,beta-dihydroxyacid dehydratase,

2,3-dihydroxyisovalerate dehydratase,

alpha,beta-dihydroxyisovalerate dehydratase,

dihydroxy acid dehydrase,

DHAD,

and 2,3-dihydroxy-acid hydro-lyase.

References

Dihydroxy-acid dehydratase Wikipedia

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