Formula C9H14N2O6 | Molar mass 246.217 g/mol | |
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Gene music using protein sequence of dus4l dihydrouridine synthase 4 like
Dihydrouridine (abbreviated as D, DHU, or UH2) is a pyrimidine which is the result of adding two hydrogen atoms to a uridine, making it a fully saturated pyrimidine ring with no remaining double bonds. D is found in tRNA and rRNA molecules as a nucleoside; the corresponding nucleobase is 5,6-dihydrouracil.
Contents
- Gene music using protein sequence of dus4l dihydrouridine synthase 4 like
- Gene music using protein sequence of dus2 dihydrouridine synthase 2
- References

Because it is non-planar, D disturbs the stacking interactions in helices and destabilizes the RNA structure. D also stabilizes the C2’-endo sugar conformation, which is more flexible than the C3’-endo conformation, and this effect is propagated to the 5’-neighboring residue. Thus, while pseudouridine and 2’-O-methylations stabilize the local RNA structure, D does the opposite.

tRNA of organisms that grow at low temperatures (psychrophiles) have high 5,6-dihydrouridine levels (40-70% more on average) which provides the necessary, local, flexibility of the tRNA at or below the freezing point.

Gene music using protein sequence of dus2 dihydrouridine synthase 2



