Formula C19H21N7O6 | Molar mass 443.414 g/mol | |
Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase. Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
References
Dihydrofolic acid Wikipedia(Text) CC BY-SA