Bioavailability 25% (Oral) Molar mass 295.379 g/mol Protein binding 80% | ATC code N06AA08 (WHO) Metabolism CAS ID 4498-32-2 | |
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AHFS/Drugs.com International Drug Names Legal status In general: ℞ (Prescription only) | ||
How to pronounce dibenzepin
Dibenzepin (Noveril, Anslopax, Deprex, Ecatril, Neodit, Victoril) is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression. It has similar efficacy and effects relative to other TCAs like imipramine but with fewer side effects. Dibenzepin acts as a norepinephrine reuptake inhibitor, potent antihistamine, and weak anticholinergic. It lacks any 5-HT2 antagonistic properties.
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Chronic pain
Like other tricyclic antidepressants, dibenzepin may have potential use in the treatment of chronic neuropathic pain.
Overdose
As tricyclic antidepressants have a relatively narrow therapeutic index, the likelihood of overdose (both accidental and intentional) is fairly high and should be considered carefully by the prescribing physician prior to patient use. Symptoms of overdose are similar to those of other tricyclic antidepressants, with cardiac toxicity (due to inhibition of sodium and calcium channels) generally occurring before the threshold for serotonin syndrome is reached. Due to this risk, tricyclic antidepressants are rarely selected as the first line treatment for depression.