EC number 3.5.4.26 IntEnz IntEnz view ExPASy NiceZyme view | CAS number 68994-19-4 BRENDA BRENDA entry KEGG KEGG entry | |
In enzymology, a diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) is an enzyme that catalyzes the chemical reaction
2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2OThus, the two substrates of this enzyme are 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and H2O, whereas its two products are 5-amino-6-(5-phosphoribosylamino)uracil and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds (specifically in cyclic amidines). The systematic name of this enzyme class is 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase. This enzyme participates in riboflavin metabolism.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2B3Z, 2D5N, 2G6V, 2HXV, 2O7P, and 2OBC.