ATC code none CAS Number 125-73-5 ChemSpider 10489895 Molar mass 257.371 g/mol | Legal status US: Unscheduled PubChem CID 5360697 UNII 04B7QNO9WS | |
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Medical vocabulary what does dextrorphan mean
Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextrorotatory-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan.
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Pharmacology
The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist as well as essentially inactive as a serotonin reuptake inhibitor, but retains DXMs activity as a norepinephrine reuptake inhibitor. Dextrorphan has a notably longer half-life than its parent compound, and therefore has a tendency to accumulate in the blood after repeated administration of normally dosed dextromethorphan formulations.
Legality
Dextrorphan was formerly a Schedule I controlled substance in the United States, but was unscheduled on October 1, 1976.