CAS Number 22161-81-5 ChemSpider 580922 | PubChem CID 667550 Molar mass 254.2806 g/mol | |
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AHFS/Drugs.com International Drug Names ATC code M01AE17 (WHO) M02AA27 (WHO) Legal status UK: POM (Prescription only) | ||
Dexketoprofen tramadol is effective against moderate to severe pain post total hip arthroplasty
Dexketoprofen is a non-steroidal anti-inflammatory drug. It is manufactured by Menarini, under the tradename Keral. It is available in the UK, as dexketoprofen trometamol, as a prescription-only drug and in Latin America as Enantyum, produced by Menarini. Also, in Italy and Spain it is available as an over-the-counter drug (OTC) under the tradenames Enantyum, and Ketesgel, respectively. In Latvia, Lithuania and Estonia it is available as an over-the-counter drug (OTC) under tradename Dolmen. In Mexico it is available in tablet form as "Stadium" made by Menarini. It is the dextrorotatory stereoisomer of ketoprofen.
Contents
- Dexketoprofen tramadol is effective against moderate to severe pain post total hip arthroplasty
- Medical uses
- Side effects
- Pharmacology
- References
Medical uses
Short-term treatment of mild to moderate pain, including dysmenorrhoea.
Side effects
It may cause dizziness and therefor patients should not drive or operate heavy machinery or vehicles until they are familiar with how dexketoprofen affects them. Concomitant use of alcohol and other sedatives may potentiate this effect. In a small subset of individuals, the dizziness may be intolerable and require transition to an alternative treatment.
Pharmacology
Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain. Along with Peripheral analgesic action it possesses central analgesic action.