Despaigne is a Cuban surname. People with this name include:
Alfredo Despaigne, a Cuban baseball playerJoël Despaigne, a Cuban volleyball playerLázaro Martínez Despaigne, a Cuban sprinterOreidis Despaigne, a Cuban judokaOdrisamer Despaigne, a Cuban baseball playerRolando Jurquin Despaigne, a Cuban volleyball playerYordanis Despaigne, a Cuban boxerYosvany Despaigne, a Cuban judoka