Species Human Entrez 79139 | Human Mouse Ensembl ENSG00000136986 | |
 | ||
Aliases DERL1, DER-1, DER1, derlin 1 External IDs MGI: 1915069 HomoloGene: 11483 GeneCards: DERL1 | ||
Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a protein that in humans is encoded by the DERL1 gene. It is a member of the rhomboid-like clan of polytopic membrane proteins.
Contents
Function
Derlin-1 is part of a complex (that includes VIMP, SEL1, HRD1, and HERP) that mediates endoplasmic-reticulum-associated degradation (ERAD) that detects misfolded proteins in the endoplasmic reticulum and targets them for destruction.
Clinical significance
Derlin 1 (DERL1) is up-regulated in metastatic canine mammary tumors as part of the unfolded protein response.
References
Derlin-1 Wikipedia(Text) CC BY-SA