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Dennis S Charney

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Dennis Charney


Biological psychiatry

Dennis S. Charney Encouraging Innovation at the Icahn School of Medicine at

Alma mater
Resilience: The Science of Mastering Life's Greatest Challenges

Penn State Milton S. Hershey Medical Center, Yale School of Medicine

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Dennis S. Charney is an American biological psychiatrist and researcher, one of the world's leading experts in the neurobiology and treatment of mood and anxiety disorders. He is the author of Neurobiology of Mental Illness, The Physician's Guide to Depression and Bipolar Disorders and Molecular Biology for the Clinician, as well as the author of over 500 original papers and chapters.


Dennis S. Charney httpsuploadwikimediaorgwikipediacommonsthu

He is a Professor of Psychiatry, Professor of Neuroscience and Professor of Pharmacology and Systems Therapeutics at Icahn School of Medicine at Mount Sinai in New York City, and currently Dean of the school.

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Dean dennis s charney delivers keynote speech at sinainnovations 2012


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Charney graduated from medical school at Penn State in 1977 and completed his residency in Psychiatry at Yale School of Medicine. A fellowship in Biological Psychiatry was completed at the Connecticut Medical Health Center.

Dennis S. Charney Dean Dennis S Charney Delivers Keynote Speech at

Charney became the Dean of Research at Mount Sinai School of Medicine in 2004, later becoming the Dean for Academic and Scientific Affairs, finally succeeding Kenneth L. Davis as Dean of the Icahn School of Medicine at Mount Sinai in 2007.

He has been named among the top 3 most highly cited authors of psychiatric research in the decade ending in 2000 by the Institute for Scientific Information, and listed in every edition of the “Best Doctors in America” since 1992.

He owns patents in dopamine and noradrenergic reuptake inhibitors in treatment of schizophrenia and in intranasal administration of ketamine to treat depression.

He was elected to the Institute of Medicine in 2000.

On the morning August 29, 2016, Dennis Charney was shot by Hengjun Chao, as he left Lange’s Deli in his hometown of Chappaqua, New York. Chao was identified as a former Mount Sinai faculty member who had been fired in 2010 for research fraud. Chao remained at the scene and was arrested and charged with attempted murder by New Castle police after the shooting. The trial began on June 5, 2017 and eight days later, on June 13, Chao was found guilty on all charges in Westchester County Court in White Plains. He was sentenced to 28 years in prison.

Affiliations and positions

  • Principal Investigator, VA National Center for Posttraumatic Stress Disorder and the NIMH Yale Mental Health Clinical Research Center.
  • Member, Food and Drug Administration Psychopharmacologic Drug Advisory Committee
  • Editorial Committee, Biological Psychiatry, a Publication of the Society of Biological Psychiatry
  • Former Chair, Board of Scientific Counselors for the National Institute of Mental Health
  • Former Chair, Scientific Advisory Board of the Anxiety Disorders Association of America (ADAA)
  • Former Chair, Depression and Bipolar Support Alliance (DBSA) Scientific Advisory Board
  • Past President, American College of Neuropsychopharmacology
  • Member, Scientific Advisory Board of the National Alliance for Research on Schizophrenia and Depression (NARSAD, now known as the Brain & Behavior Research Foundation)
  • Member, National Alliance for the Mentally Ill (NAMI)
  • Former Scientific Director, NIMH Strategic Plan for Mood Disorder Research in 2002.
  • Awards and honors (partial list)

  • 2017 Ketamine for Treatment-Resistant Depression – Named One of Top 10 on 2017 Health Care Innovations List
  • 2017 American Heart Association Heart of Gold Award
  • 2015 The World's Most Influential Minds
  • 2014 Distinguished Alumni Award from the Pennsylvania State University School of Medicine
  • 2014 The World’s Most Influential Scientific Minds
  • 2012 Jacobi MEdallion Award, Icahn School of Medicine at Mount Sinai
  • 2009 ACNP Julius Axelrod Mentorship Award
  • 2006 The Gold Medal Award from the Society of Biological Psychiatry
  • 2004 CINP-Lilly Neuroscience Clinical Research Award
  • 2004 The American Psychiatric Association Award for Research
  • 2002 The Heinz Lehman Award from the New York State Department of Mental Health
  • 1999 The American College of Psychiatrists Award for Depression Research
  • 1999 The Edward A. Strecker Award from Pennsylvania Hospital and the University of Pennsylvania
  • 1999 The Edward J. Sacher Award from Columbia University
  • 1999 The Gerald L. Klerman Lifetime Achievement Award from the Depression and Bipolar Support Alliance (DBSA)
  • 1994-1995 Anna Monika Foundation Award for Research in Affective Disorders
  • 1992 Daniel H. Efron Research Award from the American College of Neuropsychopharmacology
  • Books

  • 2013 Charney DS, Nestler EJ, Buxbaum JD, Sklar Pamela (eds). Neurobiology of Mental Illness, New York, NY, Oxford University Press, Fourth Edition ISBN 0199398461
  • 2011 Southwick SM, Litz BT, Charney DS, Friedman MJ Resilience and Mental Health: Challenges Across the Lifespan, Cambridge University Press ISBN 0521898390
  • 2012 Charney DS, Southwick SM Resilience: The Science of Mastering Life’s Greatest Challenges, Cambridge University Press ISBN 0521195632
  • 2009 Stress-induced and Fear Circuitry Disorders: Refining the Research Agenda for Dsm-v by Gavin Andrews, Dennis S. Charney, Paul J. Sirovatka, Darrel A. Regier, American Psychiatric Publishing, ISBN 0-89042-344-X
  • 2006 The Physician's Guide to Depression & Bipolar Disorders by Dennis S. Charney, Lydia Lewis, McGraw-Hill, ISBN 0-07-144175-1 (0-07-144175-1)
  • 2003 Molecular Biology for the Clinician, by Dennis S. Charney, American Psychiatric Press, ISBN 978-1-58562-113-2
  • 2002 Pediatric Psychoparmacology: Principles and Practice by James F. Leckman, Dennis S. Charney, Lawrence Scahill, Andres Martin, Oxford Univ Pr, ISBN 0-19-514173-3 (0-19-514173-3)
  • 2002 Neuropsychopharmacology: The Fifth Generation of Progress by American College of Neuropsychopharmacology and Joseph T. Coyle and Charles Nemeroff and Dennis Charney and Kenneth L. Davis, Hardcover, Lippincott Williams & Wilkins, ISBN 0-7817-2837-1 (0-7817-2837-1)
  • 1999 Neurobiology of Mental Illness by Eric J. Nestler, Dennis S. Charney, Oxford Press, ISBN 0-19-518980-9 (0-19-518980-9)
  • 1995 Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder by Matthew J. Friedman, Dennis S. Charney, Ariel Y. Deutch, Lippincott Williams & Wilkins, ISBN 0-7817-0177-5 (0-7817-0177-5)
  • Publications

  • Trauma and Resilience in the Third Year of Medical School: A Prospective Study of the Effects of Clinical Rotations on Student Well-being. Haglund M, aan het Rot M, Cooper N, Muller D, Southwick SM, Charney DS. Academic Medicine, February 2009; 84(2):258-68. doi:10.1097/ACM.0b013e31819381b1 PMID 19174682
  • Enduring mental health morbidity and social function impairment in world trade center rescue, recovery, and cleanup workers: the psychological dimension of an environmental health disaster. Stellman JM, Smith RP, Katz CL, Sharma V, Charney DS, Herbert R, Moline J, Luft BJ, Markowitz S, Udasin I, Harrison D, Baron S, Landrigan PJ, Levin SM, Southwick S. Environ Health Perspect, 2008 doi:10.1289/ehp.11164 PMID 18795171
  • Novel drugs and therapeutic targets for severe mood disorders. Mathew SJ, Manji HK, Charney DS. Neuropsychopharmacology. 2008 Aug;33(9):2080. Epub 2008 Jun 4. PMID 18172433
  • Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist. Horn TL, Harder JB, Johnson WD, Curry PT, Parchment RE, Morrissey RL, Mellick PW, Calis KA, Gold PW, Rice KC, Contoreggi C, Charney DS, Cizza G, Glaze ER, Tomaszewski JE, McCormick DL. Toxicology. 2008 Jun 3;248(1):8-17. Epub 2008 Mar 13. doi:10.1016/j.tox.2008.03.002 PMID 18423834
  • Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. Mathew SJ, Price RB, Charney DS. Am J Med Genet C Semin Med Genet. 2008 May 15;148(2):89-98. doi:10.1002/ajmg.c.30172 PMID 18412102
  • Response to Emotional Expressions in Generalized Social Phobia and Generalized Anxiety Disorder: Evidence for Separate Disorders. Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D, Vythilingam M, Finger E, Mondillo K, Jacobs M, Charney DS, Blair RJ, Drevets WC, Pine DS. American Journal of Psychiatry. 2008 May 15. doi:10.1176/appi.ajp.2008.07071060 PMID 18483136
  • Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder. Mathew SJ, Price RB, Mao X, Smith EL, Coplan JD, Charney DS, Shungu DC. Biological Psychiatry. 2008 May 1;63(9):891-8. doi:10.1016/j.biopsych.2007.09.012 PMID 18028881
  • Association between level of emotional intelligence and severity of anxiety in generalized social phobia. Jacobs M, Snow J, Geraci M, Vythilingam M, Blair RJ, Charney DS, Pine DS, Blair KS. Journal of Anxiety Disorder. 2008 Mar 13. doi:10.1016/j.janxdis.2008.03.003 PMID 18439799
  • Mental health of workers and volunteers responding to events of 9/11: review of the literature. Bills CB, Levy NA, Sharma V, Charney DS, Herbert R, Moline J, Katz CL. doi:10.1002/msj.20026 PMID 18500712
  • Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression. Czermak C, Hauger R, Drevets WC, Luckenbaugh DA, Geraci M, Charney DS, Neumeister A. Journal of Affective Disorder. 2008 Feb 15. doi:10.1016/j.jad.2008.01.014 PMID 18281099
  • Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Masten CL, Guyer AE, Hodgdon HB, McClure EB, Charney DS, Ernst M, Kaufman J, Pine DS, Monk CS. Child Abuse Negl. 2008 Jan;32(1):139-53. Epub 2007 Dec 21. doi:10.1016/j.chiabu.2007.09.006 PMID 18155144
  • Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC. Biological Psychiatry. 2007 Oct 15;62(8):870-7. Epub 2007 Aug 2. doi:10.1016/j.biopsych.2007.03.016 PMID 17678634
  • Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A. Kling MA, Alesci S, Csako G, Costello R, Luckenbaugh DA, Bonne O, Duncko R, Drevets WC, Manji HK, Charney DS, Gold PW, Neumeister A. Biological Psychiatry. 2007 Aug 15;62(4):309-13. doi:10.1016/j.biopsych.2006.09.033 PMID 17178112
  • Diagnosing bipolar disorder in trauma exposed primary care patients. Graves RE, Alim TN, Aigbogun N, Chrishon K, Mellman TA, Charney DS, Lawson WB. Bipolar Disorder. 2007 Jun;9(4):318-23. doi:10.1111/j.1399-5618.2007.00449.x PMID 17547578
  • Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Nemeroff CB, Kalali A, Keller MB, Charney DS, Lenderts SE, Cascade EF, Stephenson H, Schatzberg AF. Arch Gen Psychiatry. 2007 Apr;64(4):466-72. doi:10.1001/archpsyc.64.4.466 PMID 17404123
  • Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJ, Fromm S, Charney DS, Leibenluft E, Ernst M, Pine DS. Arch Gen Psychiatry. 2007 Jan;64(1):97-106. doi:10.1001/archpsyc.64.1.97 PMID 17199059
  • References

    Dennis S. Charney Wikipedia