ATC code C09AA12 (WHO) PubChem CID 5362116 UNII W77UAL9THI | CAS Number 83435-66-9 ChemSpider 4514931 Molar mass 452.542 g/mol | |
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AHFS/Drugs.com International Drug Names | ||
Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug in some European and Asian countries but not in America. It is taken orally, available in 15mg and 30mg tablets.
Mechanism
Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.
References
Delapril Wikipedia(Text) CC BY-SA