Degen is a surname. Notable people with the surname include:
Carl Ferdinand Degen (born 1766), Danish mathematicianWilhelm Degen III (born 1964), German engineerPhilipp Degen (born 1983), Swiss footballerBruce Degen (born 1945), American author and illustratorDavid Degen (born 1983), Swiss footballerPaul Degen (1941–2007), Swiss artistSilvije Degen (born 1942), Croatian politicianKurt Degen, movie poster artistÁrpád Degen, Hungarian biologist and botanistBob Degen (born 1944), American jazz pianistJürgen Degen (born 1967), German footballer