From their suburban home, Doctor Gordon Mortley and his sister Nurse Edith run Shady Palms Clinic, a facility that takes in physically or mentally ill indigents sent to them by the county. In reality, the Mortleys are con artists who murder their patients (usually during "surgeries" performed on them by Gordon) and continue billing the state for their care afterward. The only permanent resident of the clinic is the alcoholic Louise Kagel, who Gordon supplies with liquor in exchange for sex. One day, a new social services worker named Faith Chandler drops off John Davis, a man afflicted with tuberculosis. Edith smothers John, and Gordon buries his body, though he is later forced to dig it up and crudely puppeteer it to create the illusion that Davis is still alive when Faith asks to check in on him after bringing Charles Bedowski, who has a heart condition, to Shady Palms.
After Faith's visit, Edith and Gordon kill Bedowski while attempting to replace his heart with a dead dog's; during the procedure, the dog's heart is grabbed by the Mortley's pet cat, forcing the duo to humorously chase the feline, and deem the transplant a failure. Bedowski's remains are buried by Gordon, and Edith feeds pieces of him to the rats that live in the garage. The infestation of vermin does not go unnoticed by the authorities, and when Mr. Smith, an environmental health officer, threatens to shut the clinic down, Edith stabs him to death.
Faith herself checks into Shady Palms, and grows suspicious of the facility, which causes Edith to knife her, after feeding the woman rats she had cooked her for lunch. Louise witnesses Faith's murder, so Edith kills her with a syringe, despite Gordon's fondness for her. Edith has Gordon place the bodies of Smith, Faith, and Louise in the garage, from which their smell attracts the attention of a police lieutenant who had stopped by to visit Charles Bedowski. Observing from a window as the lieutenant opens the garage and discovers what is inside it, a dejected Edith sits on a sofa with Gordon, and the film ends.Priscilla Alden as Nurse Edith Mortley
Albert Eskinazi as Doctor Gordon Mortley
Royal Farros as Mr. Powell/Charles Bedowski
Frances Millard as Faith Chandler
Irmgard Millard as Louise Kagel
Nick Millard as John Davis
Fred Sarra as Lieutenant Cal Bedowski
Slasher // Video released Death Nurse and its sequel on DVD in 2012. Limited to 1000 copies, the DVD includes features such as a Q&A with Nick Millard, and a commentary provided by him, Irmgard Millard, and Slasher // Video founder Jesus Terán.
Rock! Shock! Pop!'s Ian Jane called the film "fascinatingly watchable" despite its horribleness, and wrote, "The acting is amateur hour in the best/worst way possible but say what you will, the movie is something. Exactly what, it's hard to say but as far as slashers go, this one ranks down there with the cheapest of the cheap, the worst of the worse. As such, it's easy to love if you're in the right frame of mind for it. You'd be foolish to take any of it seriously, it's obvious that those making the picture weren't". Slasherpool gave Death Nurse a 2 out of 5, finding some entertainment in Priscilla Alden's performance, the death scenes, and the film's ineptness and absurdity, concluding "The premise isn't a bad one... in fact, in more capable hands, this would make a pretty good black comedy... but you get what you get".