DeSantis is a common surname. Well-known people with this name include:
Antonio De Santis, Italian poetEric DeSantis, writer of comic booksGiuseppe De Santis, Italian film directorLouis DeSantis, American prosthodontic dentist and NYU College of Dentistry facultyJaclyn DeSantis, American actressJoe De Santis, American radio and television personalityJohn DeSantis, Canadian actorMarko DeSantis, American rock guitarist for SugarcultNick DeSantis, Canadian soccer playerOrchidea De Santis, Italian actressPasqualino De Santis, Italian cinematographerStanley DeSantis, American actor and businessmanTullio Francesco DeSantis, American contemporary artist, writer, and teacherTony DeSantis, American entrepreneurJohn DeSantis, American radio personalityRon DeSantis, US congressman from Florida