De Clerck is a Dutch occupational surname, particularly common in Flanders. In the province of West Flanders the name is usually concatenated to Declerck. People with the surname include:
Albert De Clerck (1914–1974), Belgian politician and government minister
Carl Alexander Clerck (1709–1765), Swedish entomologist and arachnologist
Hendrik de Clerck (c. 1560 – 1630), Flemish painter
Jacques de Clerck (c. 1582 – 1624), Antwerp-born Dutch merchant, admiral, and explorer
Jeanne Albertine Colin-De Clerck (born 1924), Belgian composer
Marc de Clerck (born 1949), Belgian football goalkeeper
Richard Declerck (1899–1986), Belgian lawyer and politician
Roger De Clerck (1924–2015), Belgian entrepreneur
Stefaan Maria Joris Yolanda De Clerck (born 1951), Belgian politician
