De Clerck is a Dutch occupational surname, particularly common in Flanders. In the province of West Flanders the name is usually concatenated to Declerck. People with the surname include:
Albert De Clerck (1914–1974), Belgian politician and government ministerCarl Alexander Clerck (1709–1765), Swedish entomologist and arachnologistHendrik de Clerck (c. 1560 – 1630), Flemish painterJacques de Clerck (c. 1582 – 1624), Antwerp-born Dutch merchant, admiral, and explorerJeanne Albertine Colin-De Clerck (born 1924), Belgian composerMarc de Clerck (born 1949), Belgian football goalkeeperRichard Declerck (1899–1986), Belgian lawyer and politicianRoger De Clerck (1924–2015), Belgian entrepreneurStefaan Maria Joris Yolanda De Clerck (born 1951), Belgian politician