De Beer is a Dutch and Afrikaans surname, meaning "the bear". It can refer to:
Esmond Samuel de Beer (1895–1990), New Zealand bibliophile, art collector and philanthropistGavin de Beer (1899–1972), British evolutionary embryologistde:Hans de Beer (born 1957), Dutch illustrator and authorJan de Beer (c.1475–1528), Flemish painter and draughtsmanJannie de Beer (born 1971), South African rugby playerJoos de Beer (<1535-1591), Dutch painterLonell de Beer (born 1980), South African cricketerRacheltjie de Beer (1831-1843), Afrikaner heroine who may be fictionalSue de Beer (born 1973), American contemporary artistWillem de Beer (born 1988), South African sprinterWolfgang de Beer (born 1964), German footballerZach de Beer (1928–1999), South African politician and businessman