Higham started playing lead guitar with British rockabilly bands in the late 1980s. By the mid-1990s, he and the bass player Mick Wigfall had created the band that would become his main gigging and recording project: Darrel Higham & The Enforcers. Higham's solo projects include session work as guitarist with Chrissie Hynde, Jeff Beck, Rocky Burnette, Billy Lee Riley, Shakin' Stevens (on the 1999 UK tour). Eddie Cochran's last road band - The Kelly Four - employed Higham as their front man for a six-month period in 1992 for gigs and recordings in the US.
In 1996, he also appeared in London's Prince Of Wales Theatre playing the role of Scotty Moore and Eddie Cochran for 8 months in a revival of Jack Good's Elvis: The Musical. This would lead to further roles as Eddie Cochran in touring theatre shows around the UK for a couple of years afterwards.
Higham co-owns Embassy Studios, a sixteen-track analogue recording studio near Basingstoke, with Foot Tapping Records boss, Clive Duffin. They also run a small recording label, Ambassador Records. Higham is endorsed by Peavey and plays their amplifiers exclusively. He also helped design the company's first semi acoustic guitar - The Rockingham. He now plays a variety of guitars including a Gretsch White Falcon, a Gibson ES-5 and a Kay Thin Line re-issue.
In 2006, Darrel found himself in California touring in support of WILD Records. After providing lead guitar on various WILD band recordings, he and Reb Kennedy (WILD Records founder) decided to record an album of Darrel's favourite rockabilly songs. The tracks were lost for some time, but recently resurfaced and the resulting 12-track album, "Wild In Hollywood" was finally released in March of 2013.
In 2007, Higham formed Kat Men with former Stray Cats drummer Slim Jim Phantom. The duo recorded its debut album, Kat Men, with former Guns N' Roses guitarist Gilby Clarke.
From 2008 onwards he has also found success as lead guitarist in the Imelda May band, whose albums Love Tattoo and Mayhem reached number one in Ireland, as well as having toured the US as support acts to Jeff Beck and Jamie Cullum.
He is married to the singer Imelda May; however, on 17 July 2015, May announced the couple's decision to separate after 13 years of marriage. After the separation, Higham also decided to leave May's band to focus on his solo career.
In 2011 he shared the lead vocal duties with May on the Jeff Beck DVD, A Rock 'n' Roll Party, and reunited Kat Men.
Higham is a fan of Sunderland AFC, a football team in the Premier League.Don't Forget Me - The Eddie Cochran Story (with Julie Mundy; Mainstream Publications, 2000)