DOCK (protein)

Updated on Jan 12, 2024

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Symbol Ded_cyto InterPro IPR010703 SUPERFAMILY 1wg7		Pfam PF06920 SCOP 1wg7 CDD cd11684

DOCK (Dedicator of cytokinesis) is a family of related proteins involved in intracellular signalling networks. Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac and Cdc42. DOCK family proteins are categorised into four subfamilies based on their sequence homology:

DOCK-A subfamily

Dock180 (also known as Dock1)

Dock2

Dock5

DOCK-B subfamily

Dock3 (also known as MOCA and PBP)

Dock4

DOCK-C subfamily (also known as Zir subfamily)

Dock6 (also known as Zir1)

Dock7 (also known as Zir2)

Dock8 (also known as Zir3)

DOCK-D subfamily (also known as Zizimin subfamily)

Dock9 (also known as Zizimin1)

Dock10 (also known as Zizimin3)

Dock11 (also known as Zizimin2)

References

DOCK (protein) Wikipedia

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