Species Human Entrez 1759 | Human Mouse Ensembl ENSG00000106976 | |
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Aliases DNM1, Dynamin-1, DNM, EIEE31, dynamin 1 External IDs MGI: 107384 HomoloGene: 123905 GeneCards: DNM1 | ||
Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.
Contents
Function
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
Interactions
DNM1 has been shown to interact with: