DNA oxidative demethylase

Updated on Dec 19, 2024

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EC number 1.14.11.33 BRENDA BRENDA entry KEGG KEGG entry		IntEnz IntEnz view ExPASy NiceZyme view MetaCyc metabolic pathway

DNA oxidative demethylase (EC 1.14.11.33, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming). This enzyme catalyses the following chemical reaction

DNA-base-CH₃ + 2-oxoglutarate + O₂ ⇌ DNA-base + formaldehyde + succinate + CO₂

DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.

References

DNA oxidative demethylase Wikipedia

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