Trisha Shetty (Editor)

DNA 3 methyladenine glycosylase II

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EC number
  
3.2.2.21

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
89287-38-7

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

DNA-3-methyladenine glycosylase II (EC 3.2.2.21) is an enzyme that catalyses the following chemical reaction:

Contents

Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine

Involved in the removal of alkylated bases from DNA in Escherichia coli.

Evolution

Through the process of convergent evolution, there are at least two unrelated protein folds that share the same DNA-3-methyladenine glycosylase activity. The first, the AlkA N-terminal domain, is found in bacteria Pfam PF06029. The second, methylpurine-DNA glycosylase (MPG) Pfam PF02245 is found in vertebrates including humans.

Nomenclature

DNA-3-methyladenine glycosylase II is also known as

  • deoxyribonucleate 3-methyladenine glycosides II
  • 3-methyladenine DNA glycosylase II
  • DNA-3-methyladenine glycosides II
  • AlkA
  • alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)

    • References

    DNA-3-methyladenine glycosylase II Wikipedia
    (Text) CC BY-SA