Entrez 1755 | Ensembl ENSG00000187908 | |
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Aliases DMBT1, GP340, muclin, SAG, deleted in malignant brain tumors 1 External IDs MGI: 106210 HomoloGene: 68990 GeneCards: DMBT1 | ||
Deleted in malignant brain tumors 1 protein is a protein that in humans is encoded by the DMBT1 gene.
Contents
Function
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system.
Interactions
DMBT1 has been shown to interact with Surfactant protein D.