Entrez 9229 | Ensembl ENSG00000170579 | |
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Aliases DLGAP1, DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1, hGKAP, discs large homolog associated protein 1, DLG associated protein 1 External IDs MGI: 1346065 HomoloGene: 31258 GeneCards: DLGAP1 | ||
Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a protein that in humans is encoded by the DLGAP1 gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post synaptic density.
Contents
Function
This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK and PSD-95 proteins, facilitating the assembly of the post synaptic density of neurons. Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.
Interactions
DLGAP1 has been shown to interact with:
The interaction with PSD95 and S-SCAM is mediated by the GUK domain and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.