Species Human Entrez 1716 | Human Mouse Ensembl ENSG00000114956 | |
Aliases DGUOK, deoxyguanosine kinase, MTDPS3, dGK External IDs MGI: 1351602 HomoloGene: 8456 GeneCards: DGUOK |
Deoxyguanosine kinase, mitochondrial is an enzyme that in humans is encoded by the DGUOK gene.
Function
In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.
References
DGUOK Wikipedia(Text) CC BY-SA