Species Human Entrez 7913 | Human Mouse Ensembl ENSG00000124795 | |
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Aliases DEK, D6S231E, DEK proto-oncogene External IDs MGI: 1926209 HomoloGene: 2593 GeneCards: DEK | ||
Function
This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.
Interactions
DEK interacts with TFAP2A.
References
DEK (gene) Wikipedia(Text) CC BY-SA