Entrez 11325 | Ensembl ENSG00000198231 | |
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Aliases DDX42, DDX42P, RHELP, RNAHP, SF3B8, SF3b125, DEAD-box helicase 42 External IDs MGI: 1919297 HomoloGene: 49137 GeneCards: DDX42 | ||
Function
This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.
Interactions
DDX42 has been shown to interact with SF3B1.
Model organisms
Model organisms have been used in the study of DDX42 function. A conditional knockout mouse line called Ddx42tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping