Species Human Entrez 9188 | Human Mouse Ensembl ENSG00000165732 | |
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Aliases DDX21, GUA, GURDB, RH-II/GU, RH-II/GuA, DEAD-box helicase 21 External IDs MGI: 1860494 HomoloGene: 3473 GeneCards: DDX21 | ||
Nucleolar RNA helicase 2 is an enzyme that in humans is encoded by the DDX21 gene.
Contents
Function
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription.
Interactions
DDX21 has been shown to interact with C-jun.