EC number 3.5.4.30 | ExPASy NiceZyme view MetaCyc | |
In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30) is an enzyme that catalyzes the chemical reaction
dCTP + 2 H2O
Thus, the two substrates of this enzyme are dCTP and H2O, whereas its 3 products are dUMP, diphosphate, and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.
References
DCTP deaminase (dUMP-forming) Wikipedia(Text) CC BY-SA