Species Human Entrez 10540 | Human Mouse Ensembl ENSG00000175203 | |
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Aliases DCTN2, DCTN50, DYNAMITIN, HEL-S-77, RBP50, dynactin subunit 2 External IDs MGI: 107733 HomoloGene: 4667 GeneCards: DCTN2 | ||
Dynactin subunit 2 is a protein that in humans is encoded by the DCTN2 gene.
Contents
Function
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place.
Interactions
DCTN2 has been shown to interact with MARCKSL1.