Species Human Entrez 1612 | Human Mouse Ensembl ENSG00000196730 | |
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Aliases DAPK1, DAPK, death associated protein kinase 1 External IDs MGI: 1916885 HomoloGene: 3626 GeneCards: DAPK1 | ||
Death-associated protein kinase 1 is an enzyme that in humans is encoded by the DAPK1 gene.
Contents
Function
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
In melanocytic cells DAPK1 gene expression may be regulated by MITF.
As a drug target
Depletion of DAPK1 results in inhibition of tumor cell count and volume growth in cellular and animal models of triple receptor-negative breast cancer, from individuals with p53-mutant cancers. This has not been demonstrated in actual patients.
References
DAPK1 Wikipedia(Text) CC BY-SA