Species Human Entrez 1603 | Human Mouse Ensembl ENSG00000129562 | |
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Aliases DAD1, OST2, defender against cell death 1 External IDs MGI: 101912 HomoloGene: 1027 GeneCards: DAD1 | ||
Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1 is an enzyme that in humans is encoded by the DAD1 gene.
Contents
Function
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.
Interactions
DAD1 has been shown to interact with MCL1.
References
DAD1 Wikipedia(Text) CC BY-SA