Supriya Ghosh (Editor)

DAB2

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Species
  
Entrez
  
1601

Human
  
Ensembl
  
ENSG00000153071

DAB2

Aliases
  
DAB2, DOC-2, DOC2, clathrin adaptor protein

External IDs
  
MGI: 109175 HomoloGene: 1026 GeneCards: DAB2

Disabled homolog 2 is a protein that in humans is encoded by the DAB2 gene.

Contents

Function

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta).

Interactions

DAB2 has been shown to interact with:

References

DAB2 Wikipedia


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