D Deprenyl

-Deprenyl, also known as or dextro-N-propargyl-N-methylamphetamine, is an MAO-B inhibitor that metabolizes into -amphetamine and -methamphetamine and is therefore also a norepinephrine-dopamine releasing agent. It is the opposite enantiomer of -deprenyl (selegiline).

L-Deprenyl, also an MAO-B inhibitor, metabolizes to L-amphetamine and L-methamphetamine, which are both norepinephrine releasing agents. In contrast, D-deprenyl additionally has dopaminergic effects and has been found to be reinforcing in scientific research, whereas L-deprenyl is not known to have any appreciable psychological reinforcement.

In addition to its actions as an MAO-B inhibitor and NDRA, D-deprenyl has been found to bind with high affinity to the σ₁ receptor (K_i = 79 nM) similarly to various other amphetamine derivatives. Its L-isomer, selegiline, binds with 3.5-fold lower affinity in comparison.