D'Antoni is an Italian surname. Notable people with the surname include:
Alessandro D'Antoni (born 1988), Italian footballerAndrea D'Antoni (1811–1868), Italian painterAntonio D'Antoni (1801–1859), Italian opera composer and conductorDan D'Antoni (born 1947), Italian-American basketball coach and former player, brother of Mike D'AntoniDavid D'Antoni (born 1979), Italian footballerMike D'Antoni (born 1951), Italian-American NBA basketball coach and former player, brother of Dan D'AntoniPhilip D'Antoni (born 1929), American film producer